Gene with Variants

Precision Medicine Experts at RPRDx

Gene with Variants

Genetic variation can affect drug efficacy and likelihood of the occurrence of an adverse drug reaction. Our WPS test includes both common and rare variants, in order to generate accurate and ethnicity-unbiased genotype results and actionable interpretation*.

WPS was developed from a highly comprehensive PGx assay that analyzes 4,627 markers within nearly 1,200 genes1. Due to the large scope of the test, only the genes included in the Applied Biosystems AxiomTM Analysis suite software translational table1 are presented here. If the genes or markers you are interested in are not shown in the list, there is a good chance that they are still included on WPS. Please contact us for more information.

Genes with corresponding variants

WT
F17L
N21D
N44S
A80E
G185V
S400N
E566K
R593C
A599T
V801M
I829V
I836V
A893S
A893T
A999T
P1051A
G1063A
Q1107P
S1141T
V1251I
WT
A444V
D482G
E1186K
G238V
G982R
R1057X
R1090X
R1153C
R1268Q
R299K
R575X
WT
A1100T
E528D
I1185V
L238V
L73V
Q636X
R144X
R652G
R788Q
W658X
WT
A581V
L272P
R259K
Null
WT
A989T
D526A
G671V
R230Q
R433S
R723Q
S92F
T1337A
T1345M
V353M
WT
602fs
A1450P
A1450S
A1450T
C1515Y
D333G
E893K
E893Q
F39Y
F562L
I1036T
I1173F
I670T
I982V
K1299Q
K495E
L849R
M246L
M246V
N718S
P1291L
R1066X
R1181L
R1181Q
R1310X
R353H
R768W
S789C
S789F
T1273A
T486I
V1188E
V417I
Y967X
WT
A528V
R1297H
L1362V
WT
631fs
C171G
E757K
G187W
K304N
WT
1147fs
T1383N
Y1202X
WT
H632Q
R1268Q
V665A
V848M
WT
631fs
701fs
E382K
L1014X
R248X
R836X
S1369A
V1572I
WT
A1513T
WT
A528T
D296H
E334X
F208S
L525R
Q126X
Q141K
S248P
WT
I189V
L142V
Q167X
R409X
V767L
V1401L
Null
WT
c.520C>T
c.3257G>A
*1
*2
*3
WT
R98W
V206M
IVS8-2
WT
F508delCTT
G551D
WT
Null
ValB
A102T
A72S
Met
MetB
ValA
ValB
ValC
ValD
ValE
WT
C22W
*1
*2
*4
*1
*2C
*3
*4
*5
*6
*7
*8
*9
*10
*11
*13
A463G
F381L
I286T
R279G
R279W
*1A
*1C
*1D
*1F
*1K
*1L
*2
*3
*4
*5
*6
*7
*8
*9
*9+1F
*10
*11
*12
*13
*13+1F
*14
*15
*16
*17
*18
*19
*20
*21
L65P
S298R
*1
*2
*3
*4
*5
*6
*7
*8
*11
W57X
*12
*13
*17
*18
*19
*20
*21
*22
*23
*24
*25
H401FS
M372V
R355X
R468FS
W57X
*1
*3
*4
*5
*6
*8
*10
P321L
*1
*1H
*2
*4
*6
*9
*11
*13
*14
*17
*20
*22
*23
*25
*26
*27
*28
*31
*35A
*35B
*37
*41
*44
A3S
I300T
K387FS
P402S
Y351H
*1
*2
*3
*4
*5
*6
*7
*8
*11
*12
*13
*14
*15
*16
*17
*18
*19
*20
*21
*22
*24
*25
*26
*27
*28
*35
*36
*37
*38
F213L
R109Q
R253H
V183I
WT
195fs
K232E
R124W
T385M
Y68X
*1
*2
*3
*4A
*4B
*5
*6
*7
*8
*9
*10
*12
*13
*14
*15
*16
*17
*18
*19
*22
*23
*24
*25
*26
*28
*34
*35
A161P
D360N
E241FS
E92D
F168L
G439FS
M74T
T302R
V113I
V331I
V394M
*1A
*1B
*1C
*2
*3
*4+1C
*5
*7
*8
*10
*11
*12
*13
*14
L390S
P404A
*1
*2
*3
*4
*5
*6
*9
*10
*11
*12
*13
*15
*16
*17
*18
*19
*20
*21
*23
*24
*25
*26
*28
*29
*30
*31
*32
*34
*36
*37
*38
*39
*40
*42
*43
*44
*45
*46
*47
*48
*49
*50
*51
*52
*53
*54
*55
*56
*57
*58
L413P
N474S
Y358C
rs9332094C
*1
*2
*3A
*3B
*4
*5
*6
*7
*8
*9
*10
*11
*12
*14
*15
*17
*18
*19
*20
*22
*23
*25
*28
*29
*31
*33
*35
*37
*38
*40
*41
*42
*43
*44
*45
*46
*47
*48
*49
*51
*53
*54
*55
*56A
*56B
*59
*62
*70
*71
*72
*73
*75
*81
*82
*84
*85
*86
*88
*89
*95
*100
*101
*102
*103
*107
*109
*114
E418K
G212E
G373S
H478Y
H94R
K281Frameshift
L421P
L91M
P325L
R173C
R365H
S311L
S467L
S486T
T470A
Y490C
rs5758550
rs133333
*1A
*1B
*2
*2+1B
*3
*4
*4+5+7A
*4+7A
*4+7A+1B
*5+1B
*5A
*5A+7A+1B
*5B
*6
*6+1B
*6+7A
*6+7C+1B
*7A
*7A+1B
*7B
*7C
*1
*2
*3
*4
*5
*6
D218N
V175L
*1
*2
*3
*4
*5
*6
*7
L378Q
*1
*2
*3
*4
*1
*2
*3
*4
*5
*6
*7
*8
*9
*10
*11
*12
*13
*14
*15
*16
*17
*18
*19
*20
*22
*23
F465FS
I193V
I431T
K96E
S252A
S252T
*1A
*1B
*2A
*2B
*3
M145I
M275I
*1
*2
*2+3
*3
*3G
*4
*5
*6
*7
*8
*8
F446S
G31FS
H30Y
I488T
L82R
S100C
S100Y
Y53C
*1A
*1B
*1C
*1D
*1E
*2
*2+1E
*1
*2
*3
*4
*5
R375C
*1
*2
*3
*2+3
G185V
L278F
L519M
P13R
W12C
WT
A119G
I24V
P122S
c.=
c.1129-5923C>G
c.1156G>T
c.1679T>G
c.1898delC
c.1905+1G>A
c.2846A>T
c.295_298delTCAT
c.2983G>T
c.557A>G
c.61C>T
c.703C>T
C29R
I543V
K259E
M166V
N635K
R21Q
R886C
R886H
S534N
V335L
V732I
WT
E1530G
Leiden
Leiden+rs6018G
rs6018G
WT
H370R
P129T
*1
*2
*3
*3+6
*5
*6
*2
*2C
*2E
*1
*3
D36G
V59I
70InsD
F81S
F182S
R238Q
R249X
E314G
R387ins8
R391T
S511fs
WT
202fs
A52T
D132H
E158K
E305X
E308G
E314K
E314X
E32K
E362Q
G148R
G148X
G503R
I199N
I486M
L360P
M66I
M82T
N61S
P153L
R387H
R387L
R492W
V257M
V277A
202A_376G_1264G
A
A-(202A_376G)
A-(680T_376G)
A-(968C_376G)
Abeno
Acrokorinthos
Alhambra
Amazonia
Amiens
Amsterdam
Anadia
Ananindeua
Andalus
Arakawa
Arg198Leu
Arg463Gly
Asahi
Asahikawa
Asp282Asn
Aures
Aveiro
B
Bajo_Maumere
Bangkok
Bangkok_Noi
Bao_Loc
Bari
Belem
Beverly_Hills
Brighton
Buenos_Aires
Calvo_Mackenna
Campinas
Canton
Cassano
Chatham
Chikugo
Chinese-1
Chinese-5
Cincinnati
Cleveland_Corum
Clinic
Coimbra_Shunde
Cosenza
Costanzo
Covao_do_Lobo
Crispim
Durham
Farroupilha
Figuera_da_Foz
Flores
Fukaya
Fushan
Gaohe
Georgia
Guadalajara
Guangzhou
Haikou
Hammersmith
Harilaou
Harima
Hartford
Hechi
Hermoupolis
Honiara
Ierapetra
Ilesha
Insuli
Iowa
Iwatsuki
Japan
Kaiping
Kalyan-Kerala
Kambos
Kamiube
Kamogawa
Kozukata
Krakow
La_Jolla
Lages
Lagosanto
Lille
Liuzhou
Loma_Linda
Ludhiana
Lynwood
Madrid
Mahidol
Malaga
Manhattan
Mediterranean
Metaponto
Mexico_City
Miaoli
Minnesota
Mira_d_Aire
Mizushima
Montalbano
Montpellier
Mt_Sinai
Munich
Murcia_Oristano
Musashino
Namouru
Nankang
Nanning
Naone
Nara
Nashville
Neapolis
Nice
Nilgiri
North_Dallas
Olomouc
Omiya
Orissa
Osaka
Palestrina
Partenope
Pawnee
Pedoplis-Ckaro
Piotrkow
Plymouth
Praha
Pro62Arg
Puerto_Limon
Quing_Yan
Radlowo
Rehevot
Rignano
Riley
Riverside
Roubaix
S_Antioco
Santa_Maria
Santiago
Santiago_de_Cuba
Sao_Borja
Seattle
Seoul
Serres
Shenzhen
Shinshu
Sibari
Sinnai
Songklanagarind
Split
Stonybrook
Sugao
Sumare
Sunderland
Surabaya
Suwalki
Swansea
Taipei
Telti_Kobe
Tenri
Thr279Pro
Tokyo
Toledo
Tomah
Tondela
Torun
Tsukui
Ube_Konan
Union
Urayasu
Utrecht
Valladolid
Vancouver
Vanua_Lava
Viangchan
Villeurbanne
Volendam
Wayne
West_Virginia
Wexham
Wisconsin
Null
Present
Null
*A
*B
*C
D147Y
*A
*B
A21T
E173K
F45C
V169I
Null
rs12979860C
rs12979860T
*4
*5
*11B
*11C
*14
*15
*17
*18
*19A
*19B
*20
*21
*22
*23
*24
*25
*27
*29
*30
S259R
T207I
*4
*5
*5E
*5I
*5L
*5M
*5N
*5O
*5P
*5S
*5X
*5Y
*6
*6G
*6H
*6I
*6J
*6K
*6M
*6O
*6P
*6V
*7
*7D
*10
*12D
*12E
*12F
*12G
*12H
*12J
*12K
*12O
*13D
*13F
*14
*14D
*14F
*14H
*14K
*17
*18
*19
*21
*23
*24
K268R
M205L
S287P
*1
*28
*37
*1
*3
*4
E154A
F171L
R236C
R379G
P500S
Q134H
WT
1571V+3933C
WT
441fs
F28Y
G419A
P537S
P586L
P586R
R459C
S117N
S117R
T451N
V21I
V450I
*1
*2
*3
M704L
R57H
WT
19fs
420delM
C88R
F160L
G220A
G220V
G38D
G401S
G465R
L23V
L85F
L85V
M440I
P283L
P341L
R287G
R287W
R488M
R488T
R61C
S14C
S14F
V408M
V461I
*1
*2A
*2B
*3A
*3D
*3E
*5
*6
*7
*8
R463K
T201M
WT
57fs
A256V
G14S
I226N
I226T
P104L
R293W
R454Q
R50H
WT
E172D
I13T
I281V
I355V
L323P
N128Y
N135I
R168C
T277N
T668S
*1A
*1B
*2
*3
*4
*5
*6
*7
*8
*9
*11
*13
*14
*15
*16
*17
*18
*21
*22
*23
*24
*25
*26
*27
*28
*29
*30
*31
*32
*33
*35
P336R
WT
281fs
695fs
A112S
I233M
*1
*2
*3
D215V
E26_T28del
R312Q
V201M
*1
*2
*2+3
*3
*3+4
*3+5
*4
*5
Null
WT
N239S
P19L
WT
K234N
P101L
P101H
R144C
*1A
*1B
*1D
*2
*3
*4
*5
*6
*7
*8
*9
A430T
E388K
G390V
I332T
K258E
L163I
Q317K
R261G
R425C
R502Q
V125I
*1
*2
*3A
*3B
*3C
*3D
*4
*5
*6
*7
*8
*9
*10
*11
*12
*13
*14
*15
*16
*17
*18
*19
*20
*21
*23
*24
*25
*26
*27
*28
*29
*30
*31
*33
*34
*35
*36
*37
*1
*6
*8
*12
*14
*15
*27
*27+28+60+80
*27+28+60+80+93
*28
*28+60+80
*28+60+80+93
*36+60
*43
*45
*60
*60+80
*62
*112
F83I
*1
*5
*6
*1a
*1e
*2a
*2a+M114I
*2c
*2d
*3a
*3a+5
*3a+M114I
*4
*6
*7
*8
*9
*10a
*10b
c.-66T>C
P177FS
T144I
*1
*2
*3a
*3b
c.-163G>A
*1
*8
L208fs
T78A
*1
*2
*3a
*3b
*3custom
*4b
*5
S70Y
*1
*4
*5
*1a
*2
*3
E216D
F109L
L105M
L110M
M212V
N118D
*1hap_I
*1hap_I+c.-276A
*1hap_III
*1hap_V
*1hap_VI
*2
*2hap_I
*3
*3hap_I
*4
*4hap_I
*5
*5hap_I
C277Y
C3W
*3
*4
*7
*9
*10
*11
*16
*17
*18
*20
*24
*29
*55
*63
*75
*76
*79
*76+79
*IA
*IB
A511P
*1
*2
*6
A500T
*1
*2
hapB
H450Y
*1a
*1b
*1c
*1d
*2a
*2g
*3
D36Y
H1
H2
H3
H4
H6
H7
H9
L128R
R58G
R98W
V29L
V45A
V66M
REFERENCES
  1. PharmacoScan™ Assay Kit https://www.thermofisher.com/order/catalog/product/903026
  2. Clinical Pharmacogenetics Implementation Consortium (CPIC)

*Haplotypes represented by mutations not present in the test are considered wild type, which for many (but not all) genes are reported as a *1 allele. The presence of other variants that are not detected in the assay may influence drug metabolism. All relevant patient information must be considered when making any dosing decision. Please contact us for additional information on haplotypes reported on the WPS assay.