Highly Actionable Precision HealthPGx Panel

DNA strand for Precision Medicine

Highly Actionable Precision HealthPGx Panel

Actionable PGx Testing Created for All Ethnicities

RPRD’s Precision HealthPGx Panel, including 25 pharmacogenetics genes, provides extensive and highly actionable insights to help healthcare providers make informed decisions regarding treatment regimens for their patients. We are proud to offer the most inclusive coverage of the PGx relevant alleles/variants that are important when analyzing diverse populations. Our test report incorporates the most up-to-date clinical and scientific guidance from the key PGx scientific and government organizations, including Clinical Pharmacogenetics Implementation Consortium (CPIC), Pharmacogene Variation (PharmVar) Consortium and the U.S. Food and  Drug Administration (FDA).

 

 

Highly Actionable

The gene coverage of the panel has been selected and curated by RPRD’s clinicians and scientists following rigorous peer-reviewed scientific evidence and industry’s highest standards of actionability. The Precision HealthPGx Panel clinical report strictly adheres to the recommendations by the CPIC clinical guidelines and the FDA drug labeling, with clear annotations and references.

Created for all ethnicities

The panel covers a broad array of genetic alleles/variants of the key PGx genes, including not only common, but also rare and ethnicity-specific alleles. This broad coverage is particularly important when analyzing diverse populations because overlooking these rare or ethnicity-specific alleles could miss clinically important genetic information for these patients. RPRD’s PGx testing transcends ethnic diversity and generates highly accurate testing results for every patient.

Extensive Coverage of Therapeutic Areas

The panel provides extensive insights to healthcare provides on patients with a variety of health conditions and needs.

Extensive clinical use
Analgesic/AnesthesiologyAnti-inflammatoryCardiovascularImmunosuppressionInfectious diseaseNeurologyHematology/OncologyPsychiatryGastroenterologyOthers
Codeine
Desflurane
Enflurane
Halothane
Hydrocodone
Isoflurane
Methoxyflurane
Oxycodone
Sevoflurane
Succinylcholine
Tramadol
Aceclofenac
Aspirin
Diclofenac
Flurbiprofen
Ibuprofen
Indomethacin
Lornoxicam
Lumiracoxib
Meloxicam
Metamizole
Nabumetone
Naproxen
Piroxicam
Tenoxicam
Clopidogrel
Warfarin
Simvastatin
Azathioprine
Tacrolimus
Abacavir
Atazanavir
Efavirenz
Peginterferon Alfa-2A
Peginterferon Alfa-2B
Ribavirin
Sulfamethoxazole
/ trimethoprim
Voriconazole
Amifampridine
Carbamazepine
Fosphenytoin
Oxcarbazepine
Phenytoin
Capecitabine
Fluorouracil
Lapatinib
Mercaptopurine
Rasburicase
Tamoxifen
Tegafur
Thioguanine
Amitriptyline
Atomoxetine
Citalopram
Clomipramine
Desipramine
Doxepin
Escitalopram
Fluvoxamine
Imipramine
Nortriptyline
Paroxetine
Sertraline
Trimipramine
Dexlansoprazole
Lansoprazole
Omeprazole
Pantoprazole
Rabeprazole
Allopurinol
Ondansetron
Tropisetron
Ivacaftor
Sulfasalazine
Clinical Report
Actionable

Gene/drug pairs are categorized based on the level of actionability and evidence.

Evidence-based

Use clinical evidence curated by the experts at RPRD from CPIC guidelines, FDA drug label information, and other peer-reviewed scientific studies.

Customizable

Select the desired gene/drug pairs applicable for each clinical practice.

Alleles tested
GenesAlleles
HLA-A *31:01rs1061235
HLA-B *15:02rs3909184; rs2844682
HLA-DQA1
rs2647087
HLA-DRB1
rs2647087
HLA-B *57:01
rs2395029
HLA-B *58:01
rs9263726
CACNA1S
CACNA1S_c.520C>T(R174W) (rs772226819); CACNA1S_c.3257G>A(R1086H) (rs1800559)
CFTR
CFTR_c.1521_1523delCTT(F508del) (rs113993960); CFTR_c.1652G>A(G551D) (rs75527207)
CYP2B6
*1; *2; *3; *4; *5; *6; *7; *8; *11; *12; *13; *14; *15; *16; *17; *18; *19; *20; *21; *22; *24; *25; *26; *27; *28; *35; *36; *37; *38; CYP2B6_15662G>A(V183I)(rs58871670); CYP2B6_18026G>A(R253H) (rs373086625); CYP2B6_15752T>C(F213L) (rs371424910)
CYP2C19
*1; *2; *3; *4A; *4B; *5; *6; *7; *8; *9; *10; *12; *13; *14; *15; *16; *17; *18; *19; *22; *23; *24; *25; *26; *28; *34; *35; CYP2C19_12834G>C(A161P) (rs181297724); CYP2C19_80248G>A(D360N) (rs144036596); CYP2C19_19194_19195insG(E241Frameshift) (rs72558185); CYP2C19_12460G>C(E92D) (rs17878459); CYP2C19_17814T>C(F168L) (rs28399510); CYP2C19_90052delG(G439Frameshift); CYP2C19_12405T>C(M74T) (rs28399505); CYP2C19_57876C>G(T302R) (rs58259047); CYP2C19_12690G>A(V113I) (rs145119820); CYP2C19_80161G>A(V331I) (rs3758581); CYP2C19_87242G>A(V394M) (rs55948420);
CYP2C8
*1A; *1B; *1C; *2; *3; *4+1C; *5; *7; *8; *10; *11; *12; *13; *14; CYP2C8_30425C>G(P404A) (rs66501115); CYP2C8_30384T>C(L390S) (rs72558194)
CYP2C9
*1; *2; *3; *4; *5; *6; *9; *10; *11; *12; *13; *15; *16; *17; *18; *19; *20; *21; *23; *24; *25; *26; *28; *29; *30; *31; *32; *34; *36; *37; *38; *39; *40; *42; *43; *44; *45; *46; *47; *48; *49; *50; *51; *52; *53; *54; *55; *56; *57; *58; CYP2C9_42612A>G(Y358C) (rs1057909); CYP2C9_47439T>C(L413P) (rs28371687); CYP2C9_50294A>G(N474S) (rs141011391); rs9332094C
CYP2D6
*1; *2; *3A; *3B; *4; *5; *6; *7; *8; *9; *10; *11; *12; *114; *14; *15; *17; *18; *19; *20; *22; *23; *25; *28; *29; *31; *33; *35; *37; *38; *40; *41; *42; *43; *44; *45; *46; *47; *48; *49; *51; *53; *54; *55; *56A; *56B; *59; *62; *70; *71; *72; *73; *75; *81; *82; *84; *85; *86; *88; *89; *95; *100; *101; *102; *103; *107; *109; CYP2D6_974C>A(L91M) (rs28371703); CYP2D6_984A>G(H94R) (rs28371704); CYP2D6_1858C>T(R173C) (rs67780109); CYP2D6_1976G>A(G212E) (rs5030866); CYP2D6_2616_2617delA(K281Frameshift) (rs28371720); CYP2D6_2938C>T(P325L) (rs140513104); CYP2D6_3265G>A(R365H) (rs1058172); CYP2D6*52_3877G>A(E418K) (rs28371733); CYP2D6_3887T>C(L421P) (rs72549345); CYP2D6_4123C>T(S467L) (rs370012110); CYP2D6_4131A>G(T470A) (rs1135835); CYP2D6_4155C>T(H478Y) (rs28371735); CYP2D6_4180G>C(S486T) (rs1135840); CYP2D6_4192A>G(Y490C) (rs199722016); Copy number variation (CNV)
CYP3A5
*1; *2; *3; *3G; *4; *5; *6; *7; *8; *9; *2+3; CYP3A5*3B_3705C>T(H30Y) (rs28383468); CYP3A5*3B_3709_3710insG(G31Frameshift) (rs200579169); CYP3A5*3L_3775A>G(Y53C) (rs72552791); CYP3A5*3D_7249T>G(L82R) (rs56244447); CYP3A5_7303C>A/G(S100Y/C) (rs41279857); CYP3A5*3K_29753T>C(F446S) (rs41279854); CYP3A5*3F_31551T>C(I488T) (rs28365085)
CYP4F2
*1; *2; *3; *2+3; CYP4F2_c.36G>C(W12C) (rs2906891); CYP4F2_c.38C>G(P13R) (rs2906890); CYP4F2_c.554G>T(G185V) (rs3093153); CYP4F2_c.832C>T(L278F) (rs4605294); CYP4F2_c.1555C>A(L519M) (rs3093200)
DPYD
DPYD_c.61C>T(R21X) (rs72549310); DPYD*7_c.295_298delTCAT(F100Frameshift) (rs72549309); DPYD_c.557A>G(Y186C) (rs115232898); DPYD*8_c.703C>T(R235W) (rs1801266); DPYD_c.1129-5923C>G(SpliceVariant) (rs75017182); DPYD*12_c.1156G>T(E386X) (rs78060119); DPYD*13_c.1679T>G(I560S) (rs55886062); DPYD*3_c.1898delC(P633Frameshift) (rs72549303); DPYD*2_c.1905+1G>A(SpliceVariant) (rs3918290); DPYD_c.2846A>T(D949V) (rs67376798); DPYD*10_c.2983G>T(V995F) (rs1801268); DPYD_c.62G>A(R21Q) (rs80081766); DPYD*9_c.85T>C(C29R) (rs1801265); DPYD_c.496A>G(M166V) (rs2297595); DPYD_c.775A>G(K259E) (rs45589337); DPYD*11_c.1003G>T(V335L) (rs72549306); DPYD*4_c.1601G>A(S534N) (rs1801158); DPYD*5_c.1627A>G(I543V) (rs1801159); DPYD_c.1905C>G/T(N635K/N) (rs3918289); DPYD*6_c.2194G>A(V732I) (rs1801160); DPYD_c.2656C>T(R886C) (rs147545709); DPYD*9B_c.2657G>A(R886H) (rs1801267)
G6PD
Class I, II, III, IV
IFNL3
rs12979860
IFNL4
rs12979860
NAT2
*4; *5; *5E; *5I; *5L; *5M; *5N; *5O; *5P;
*5S; *5X; *5Y; *6; *6G; *6H; *6I; *6J; *6K; *6M; *6O; *6P; *6V; *7; *7D; *10; *12D; *12E; *12F; *12G; *12H; *12J; *12K; *12O; *13D; *13F; *14; *14D; *14F; *14H; *14K; *17; *18; *19; *21;' *23; *24; NAT2_c.613A>T(M205L) (rs45607939); NAT2_c.803A>G(K268R) (rs1208); NAT2_c.859T>C(S287P) (rs72554618)
NUDT15
*1; *3
RYR1
RYR1_c.4711A>G(I1571V) (rs146429605); RYR1_c.11798A>G(Y3933C) (rs147136339)
SLCO1B1
*1A; *1B; *2; *3; *4; *5; *6; *7; *8; *9; *11; *13; *14; *15; *16; *17; *18; *21; *22; *23; *24; *25; *26; *27; *28; *29; *30; *31; *32; *33; *35; SLCO1B1_c.1007C>G(P336R) (rs72559747)
TPMT
*1; *2; *3A; *3B; *3C; *3D; *4; *5; *6; *7; *8; *9; *10; *11; *12; *13; *14; *15; *16; *17; *18; *19; *20; *21; *23; *24; *25; *26; *27; *28; *29; *30; *31; *33; *34; *35; *36; *37
UGT1A1
*1; *112; *12; *14; *15; *27; *28; *43; *45; *6; *60; *62; *8; UGT1A1*62/UNK_c.247T>C/A(F83L/ I) (rs56059937)
VKORC1
VKORC1_c.-1639G>A(5'UTR) (rs9923231)
BCHErs28933389

How it works?

We accept whole blood, saliva or buccal swab samples. As a healthcare provider, you can choose to collect the patient’s blood sample or have the patient collect a salvia or buccal swab sample at home with our in-home collection kit. Depending on what option you choose, we offer to send the saliva or buccal swab collection kits either directly to your office or to the patient’s home, free of charge.

Please contact us to set up the process.

 

Only a fully licensed healthcare provider treating the patient can order the test.

Please download and fill out the Test Requisition Form. Please send the completed TRF together with the patient’s whole blood sample to us or send us the TRF only and we will arrange the sample in-home collection directly with the patient.

RPRD’s pharmacogenomics testing is performed in our fully CLIA-certified clinical grade genetic testing lab.

If it is the first time you send us the patient’s sample, please contact us to establish the process.

Specimen Requirement

RPRD provides three payment options: institutional billing, patient self-pay and insurance billing. Please contact us if you would like to learn more about each of the payment options.

Ready to talk?

If you are ready to get started or still have questions, we are here to help you. Call us at (414) 316-3097 or email info@rprdx.com.

FAQ

All our tests for clinical decision-making should be ordered by a licensed healthcare provider. Pharmacists also play a critical role in integrating PGx into patient care. In the United States, in general,  pharmacists need collaborative practice agreements in place to order the test. However, certain states may have specific state laws regulating pharmacists’ ability to order and interpret lab results.

If the specimen meets our quality requirements, typical turnaround time for the test is 2 weeks.

Institutional Billing Info

Read more

Patient’s self-pay option

For the Precision HealthPGx Panel, we also offer patient self-pay option. Please contact us for more details.

Insurance Billing

Patient’s out-of-pocket cost may vary depending on the patient’s health insurance plan. RPRD will contact the patient’s insurance provider to understand the potential total out-of-pocket cost (estimated only). We promise to process the test only if the patient is comfortable with the cost. RPRD also offers Financial Assistance Program to eligible patients to help reduce the out-of-pocket costs.

RPRD’s Financial Assistance Program 

If you have any questions about your patient’s test results or need any help to understand the report, our board-certified medical geneticist and experienced PGx scientists are available to guide you through the test results and answer any questions.

We do not offer consultation to the patients directly.

 

Whole Pharmacogenomics Scan

Learn more about our most comprehensive PGx testing.

Lab accreditation

All samples are processed in our CLIA-certified diagnostic laboratory with robust quality assurance programs that surpass required diagnostic testing standards.