Next generation sequencing (NGS)

DNA strand for Precision Medicine

Next generation sequencing (NGS)

Customized NGS solutions

Next Generation Sequencing (NGS) has unique advantages in identifying novel genetic variants and discovering new genes and markers associated with particular drug response. Leveraging our decades of research experience and significant expertise in NGS technology, we are excited to work with our customers to design customized end-to-end pharmacogenomics (PGx) testing using NGS.

We provide the whole spectrum of services, including testing, analysis, interpretation, and reporting for 100% customer satisfaction.

Nex-Gen Sequencing

Early adopter of various NGS platforms


Ion Torrent

Oxford Nanopore

Whole spectrum of NGS service

Design AmpliSeq custom panel

NGS testing

In-depth data analysis

Custom Interpretation

Full applications of NGS

SNP and Indel analysis

CNV analysis

Gene expression analysis

Gene fusion analysis

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Dr. Broeckel team’s selected publications utilizing NGS:

Zhao Y, et al. A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling. Cell. 2019 Feb 7;176(4):913-27.

Owen DL, et al. Thymic Regulatory T Cells Arise via Two Distinct Developmental Programs. Nat Immunol. 2019 Feb; 20(2):195-205.

Reeme AE, et al. Human IL12RB1 Expression is Allele-biased and Produces a Novel IL12 Response Regulator. Genes Immun. 2019 Mar; 20(3):181-197.

Yu M, et al. PLCγ-dependent mTOR Signalling Controls IL-7-mediated Early B Cell Development. Nat Commun. 2017 Nov 13;8(1):1457.

Do AN, et al. Whole Exome Analyses to Examine the Impact of Rare Variants on Left Ventricular Traits in African American Participants from the HyperGEN and GENOA Studies. J Hypertens Manag. 2017; 3 (1): 025.  

Li W, et al. Comprehensive Evaluation of AmpliSeq Transcriptome, a Novel Targeted Whole Transcriptome RNA Sequencing Methodology for Global Gene Expression Analysis. BMC Genomics. 2015 Dec;16(1):1069. 

Turner AJ, et al. The Introduction of RNA-DNA Differences Underlies Interindividual Variation in the Human IL12RB1 mRNA Repertoire. Proc Natl Acad Sci USA. 2015 Dec15;112(50):15414-9.

Rehm HL, et al. ClinGen—the Clinical Genome Resource. N Engl J Med. 2015 Jun 4;372(23):2235-42.

Aggarwal P, et al. RNA Expression Profiling of Human iPSC-derived Cardiomyocytes in a Cardiac Hypertrophy Model. PLoS One. 2014 Sep 25;9(9):e108051.  

Conference poster abstracts leveraging the NGS as the main sequencing platform:

Four novel NUDT15 haplotypes relevant for treatment of acute lymphoblastic leukemia (ALL). A. Turner, et al. (Presented at the ASPHO, 2019)

Customized NGS Solutions

If you are searching for a knowledgeable laboratory with broad experience in various NGS platforms, we are the right partner for you.