CYP2D6 Genotyping

DNA strand for Precision Medicine

CYP2D6 Genotyping

One-stop solution to characterize CYP2D6

CYP2D6 is involved in the metabolism of ~25% of clinically used drugs. It is a highly polymorphic gene with over 113 distinct star (*) allele haplotypes, and many of the SNPs lead to changes in enzyme activity. CYP2D6 has complex structural arrangements. It is located next to the highly homologous pseudogene CYP2D7, leading to the generation of stable duplications, deletions and D6/D7 hybrid allele1. Correctly characterizing CYP2D6 genotype/phenotype has been one of the pressing issues that poses challenges to the pharmacogenetics community2.

Comprehensive analysis of CYP2D6

Our innovative technology offers a one-stop solution to successfully characterize CYP2D6, including identifying rare SNPs, CNVs and hybrid alleles. Whether you are looking for a CYP2D6 single gene test, or multi-gene panel including CYP2D6, we provide the unparalleled clinical grade CYP2D6 analysis trusted by the world leading healthcare systems to guide the clinical decision making3. Our comprehensive approach yields ethnicity-unbiased testing result, which is important for analyzing diverse populations4.

Doctors meeting about Standard Of Care
CYP2D6 Alleles Reported

GeneAlleles Reported
CYP2D6 *2, *3A, *3B, *4, *5, *6, *7, *8, *9, *10, *11, *12, *14, *15, *17, *18, *19, *20, *22, *23, *25, *28, *29, *31, *33, *35, *37, *38, *40, *41, *42, *43, *44, *45, *46, *47, *48, *49, *51, *52, *53, *54, *55, *56A, *56B, *59, *62, *70, *71, *72, *73, *75, *81, *82, *84, *85, *86, *88, *89, *95, *100, *101, *102, *103, *107, *109, *114, CNV (allele duplications and multiplications)

Identify rare CYP2D6 genotypes and complex structural arrangement

Characterize CYP2D6 accurately for diverse populations

custom PGx solutions

RPRD’s experience in precision medicine and its CLIA-certified laboratory offer tailored PGx solutions to meet your unique needs.

pharmacoscan solution

Comprehensive analysis of known PGx markers in a single assay for clinical trials

References
  1. PharmVar Gene CYP2D6. Pharmcogene Variation Consortium. 2019
  2. Charity, N. et al. Clin Pharmacol Ther2020. 107 (1): 154
  3. Hoffman JM, et al. Am J Med Genet C Semin Med Genet. 2014 Mar;166C(1):45.
  4. Hoshtsuki, K. et al. Genetics in Medicine. 2020. 22 (1): 232