Highly Actionable PGx 25 Gene Panel

DNA strand for Precision Medicine

Highly Actionable PGx 25 Gene Panel

Actionable PGx Testing Tailored for Multiple Ethnicities

RPRD’s PGx 25 Gene Panel provides highly actionable and extensive insights to help the healthcare providers make informed prescription decisions for the patients. We are proud to offer the most inclusive coverage of the pharmacogenetics (PGx) relevant alleles/variants that are important when analyzing diverse populations. Our test report incorporates the most up-to-date clinical and scientific guidance from the key PGx scientific and government organizations, including Clinical Pharmacogenomics Implementation Consortium (CPIC), Pharmacogene Variation Consortium (PharmVar) and Federal Drug Administration (FDA).

 

 

Highly Actionable

The gene coverage of the panel has been selected and curated by RPRD’s clinicians and scientists following strong peer-reviewed scientific evidence and industry’s highest standard of actionability. The PGx 25 Gene Panel report strictly adheres to the recommendations by the CPIC clinical guidelines and the FDA drug labeling, with clear annotations and references.

Tailored for multiple ethnicities

RPRD’s PGx 25 Gene Panel covers a broad array of genetic alleles/variants of the key PGx genes. It investigates the common, rare, and ethnicity-specific genetic alleles that are important for diverse populations. It generates inclusive and ethnicity-unbiased highly accurate testing results that the providers and patients can trust.

Extensive Coverage of Therapeutic Areas

RPRD’s PGx 25 gene panel provides extensive insights for patients with a variety of health conditions and needs.

Extensive clinical use
Analgesic/AnesthesiologyAnti-inflammatoryCardiovascularImmunosuppressionInfectious diseaseNeurologyHematology/OncologyPsychiatryGastroenterologyOthers
Codeine
Desflurane
Enflurane
Halothane
Hydrocodone
Isoflurane
Methoxyflurane
Oxycodone
Sevoflurane
Succinylcholine
Tramadol
Aceclofenac
Aspirin
Diclofenac
Flurbiprofen
Ibuprofen
Indomethacin
Lornoxicam
Lumiracoxib
Meloxicam
Metamizole
Nabumetone
Naproxen
Piroxicam
Tenoxicam
Clopidogrel
Warfarin
Simvastatin
Azathioprine
Tacrolimus
Abacavir
Atazanavir
Efavirenz
Peginterferon Alfa-2A
Peginterferon Alfa-2B
Ribavirin
Sulfamethoxazole
/ trimethoprim
Voriconazole
Amifampridine
Carbamazepine
Fosphenytoin
Oxcarbazepine
Phenytoin
Capecitabine
Fluorouracil
Lapatinib
Mercaptopurine
Rasburicase
Tamoxifen
Tegafur
Thioguanine
Amitriptyline
Atomoxetine
Citalopram
Clomipramine
Desipramine
Doxepin
Escitalopram
Fluvoxamine
Imipramine
Nortriptyline
Paroxetine
Sertraline
Trimipramine
Dexlansoprazole
Lansoprazole
Omeprazole
Pantoprazole
Rabeprazole
Allopurinol
Ondansetron
Tropisetron
Ivacaftor
Sulfasalazine
Clinical Report
Actionable

Gene/drug pairs categorized based on the level of actionability and evidence

Evidence-based

Use clinical evidence curated by the experts at RPRD, from CPIC guidelines, FDA drug label information and other peer-reviewed scientific studies.

Customizable

Select the desired gene/drug pairs that work the best for each clinical practice.

Alleles reported

GenesAlleles
HLA-A *31:01rs1061235
HLA-B *15:02rs3909184; rs2844682
HLA-DQA1
rs2647087
HLA-DRB1
rs2647087
HLA-B *57:01
rs2395029
HLA-B *58:01
rs9263726
CACNA1S
CACNA1S_c.520C>T(R174W) (rs772226819); CACNA1S_c.3257G>A(R1086H) (rs1800559)
CFTR
CFTR_c.1521_1523delCTT(F508del) (rs113993960); CFTR_c.1652G>A(G551D) (rs75527207)
CYP2B6
*1; *2; *3; *4; *5; *6; *7; *8; *11; *12; *13; *14; *15; *16; *17; *18; *19; *20; *21; *22; *24; *25; *26; *27; *28; *35; *36; *37; *38; CYP2B6_15662G>A(V183I)(rs58871670); CYP2B6_18026G>A(R253H) (rs373086625); CYP2B6_15752T>C(F213L) (rs371424910)
CYP2C19
*1; *2; *3; *4A; *4B; *5; *6; *7; *8; *9; *10; *12; *13; *14; *15; *16; *17; *18; *19; *22; *23; *24; *25; *26; *28; *34; *35; CYP2C19_12834G>C(A161P) (rs181297724); CYP2C19_80248G>A(D360N) (rs144036596); CYP2C19_19194_19195insG(E241Frameshift) (rs72558185); CYP2C19_12460G>C(E92D) (rs17878459); CYP2C19_17814T>C(F168L) (rs28399510); CYP2C19_90052delG(G439Frameshift)
CYP2C19_12405T>C(M74T) (rs28399505); CYP2C19_57876C>G(T302R) (rs58259047); CYP2C19_12690G>A(V113I) (rs145119820); CYP2C19_80161G>A(V331I) (rs3758581); CYP2C19_87242G>A(V394M) (rs55948420);
CYP2C8
*1A; *1B; *1C; *2; *3; *4+1C; *5; *7; *8; *10; *11; *12; *13; *14; CYP2C8_30425C>G(P404A) (rs66501115); CYP2C8_30384T>C(L390S) (rs72558194)
CYP2C9
*1; *2; *3; *4; *5; *6; *9; *10; *11; *12; *13; *15; *16; *17; *18; *19; *20; *21; *23; *24; *25; *26; *28; *29; *30; *31; *32; *34; *36; *37; *38; *39; *40; *42; *43; *44; *45; *46; *47; *48; *49; *50; *51; *52; *53; *54; *55; *56; *57; *58; CYP2C9_42612A>G(Y358C) (rs1057909); CYP2C9_47439T>C(L413P) (rs28371687); CYP2C9_50294A>G(N474S) (rs141011391); rs9332094C
CYP2D6
*1; *2; *3A; *3B; *4; *5; *6; *7; *8; *9; *10; *11; *12; *114; *14; *15; *17; *18; *19; *20; *22; *23; *25; *28; *29; *31; *33; *35; *37; *38; *40; *41; *42; *43; *44; *45; *46; *47; *48; *49; *51; *53; *54; *55; *56A; *56B; *59; *62; *70; *71; *72; *73; *75; *81; *82; *84; *85; *86; *88; *89; *95; *100; *101; *102; *103; *107; *109; CYP2D6_974C>A(L91M) (rs28371703); CYP2D6_984A>G(H94R) (rs28371704); CYP2D6_1858C>T(R173C) (rs67780109); CYP2D6_1976G>A(G212E) (rs5030866); CYP2D6_2616_2617delA(K281Frameshift) (rs28371720); CYP2D6_2938C>T(P325L) (rs140513104); CYP2D6_3265G>A(R365H) (rs1058172); CYP2D6*52_3877G>A(E418K) (rs28371733); CYP2D6_3887T>C(L421P) (rs72549345); CYP2D6_4123C>T(S467L) (rs370012110); CYP2D6_4131A>G(T470A) (rs1135835); CYP2D6_4155C>T(H478Y) (rs28371735); CYP2D6_4180G>C(S486T) (rs1135840); CYP2D6_4192A>G(Y490C) (rs199722016); Copy number variation (CNV)
CYP3A5
*1; *2; *3; *3G; *4; *5; *6; *7; *8; *9; *2+3; CYP3A5*3B_3705C>T(H30Y) (rs28383468); CYP3A5*3B_3709_3710insG(G31Frameshift) (rs200579169); CYP3A5*3L_3775A>G(Y53C) (rs72552791); CYP3A5*3D_7249T>G(L82R) (rs56244447); CYP3A5_7303C>A/G(S100Y/C) (rs41279857); CYP3A5*3K_29753T>C(F446S) (rs41279854); CYP3A5*3F_31551T>C(I488T) (rs28365085)
CYP4F2
*1; *2; *3; *2+3; CYP4F2_c.36G>C(W12C) (rs2906891); CYP4F2_c.38C>G(P13R) (rs2906890); CYP4F2_c.554G>T(G185V) (rs3093153); CYP4F2_c.832C>T(L278F) (rs4605294); CYP4F2_c.1555C>A(L519M) (rs3093200)
DPYD
DPYD_c.61C>T(R21X) (rs72549310); DPYD*7_c.295_298delTCAT(F100Frameshift) (rs72549309); DPYD_c.557A>G(Y186C) (rs115232898); DPYD*8_c.703C>T(R235W) (rs1801266); DPYD_c.1129-5923C>G(SpliceVariant) (rs75017182); DPYD*12_c.1156G>T(E386X) (rs78060119); DPYD*13_c.1679T>G(I560S) (rs55886062); DPYD*3_c.1898delC(P633Frameshift) (rs72549303); DPYD*2_c.1905+1G>A(SpliceVariant) (rs3918290); DPYD_c.2846A>T(D949V) (rs67376798); DPYD*10_c.2983G>T(V995F) (rs1801268); DPYD_c.62G>A(R21Q) (rs80081766); DPYD*9_c.85T>C(C29R) (rs1801265); DPYD_c.496A>G(M166V) (rs2297595); DPYD_c.775A>G(K259E) (rs45589337); DPYD*11_c.1003G>T(V335L) (rs72549306); DPYD*4_c.1601G>A(S534N) (rs1801158); DPYD*5_c.1627A>G(I543V) (rs1801159); DPYD_c.1905C>G/T(N635K/N) (rs3918289); DPYD*6_c.2194G>A(V732I) (rs1801160); DPYD_c.2656C>T(R886C) (rs147545709); DPYD*9B_c.2657G>A(R886H) (rs1801267)
G6PD
Class I, II, III, IV
IFNL3
rs12979860
IFNL4
rs12979860
NAT2
*4; *5; *5E; *5I; *5L; *5M; *5N; *5O; *5P;
*5S; *5X; *5Y; *6; *6G; *6H; *6I; *6J; *6K; *6M; *6O; *6P; *6V; *7; *7D; *10; *12D; *12E; *12F; *12G; *12H; *12J; *12K; *12O; *13D; *13F; *14; *14D; *14F; *14H; *14K; *17; *18; *19; *21;' *23; *24; NAT2_c.613A>T(M205L) (rs45607939); NAT2_c.803A>G(K268R) (rs1208); NAT2_c.859T>C(S287P) (rs72554618)
NUDT15
*1; *3
RYR1
RYR1_c.4711A>G(I1571V) (rs146429605); RYR1_c.11798A>G(Y3933C) (rs147136339)
SLCO1B1
*1A; *1B; *2; *3; *4; *5; *6; *7; *8; *9; *11; *13; *14; *15; *16; *17; *18; *21; *22; *23; *24; *25; *26; *27; *28; *29; *30; *31; *32; *33; *35; SLCO1B1_c.1007C>G(P336R) (rs72559747)
TPMT
*1; *2; *3A; *3B; *3C; *3D; *4; *5; *6; *7; *8; *9; *10; *11; *12; *13; *14; *15; *16; *17; *18; *19; *20; *21; *23; *24; *25; *26; *27; *28; *29; *30; *31; *33; *34; *35; *36; *37
UGT1A1
*1; *112; *12; *14; *15; *27; *28; *43; *45; *6; *60; *62; *8; UGT1A1*62/UNK_c.247T>C/A(F83L/ I) (rs56059937)
VKORC1
VKORC1_c.-1639G>A(5'UTR) (rs9923231)
BCHErs28933389

How it works?

RPRD accepts whole blood or saliva sample. If you choose to send your patient’s saliva sample, RPRD can send the collection kits either directly to your patient’s home, or to your office, free of charge.

Please contact us to set up the process

 

RPRD’s PGx testing is fully CLIA-certified clinical grade genetic testing. Only a fully licensed healthcare provider or a genetic counselor who treats the patient can order the test.

Please download and fill out the Test Requisition Form. Please send the completed TRF together with the patient’s sample to us, or fax it directly to RPRD and we will arrange the sample home collection directly with the patient. If an insurance billing payment option is chosen, please contact us to establish the billing process first.

Specimen Requirement

RPRD provides three payment options: insurance billing, patient self-pay and institutional billing. Please contact us if you would like to learn more about each of the payment options.

Ready to talk?

Are you ready to start or still have questions? We are here to help. Call us at +1 (414) 316-3097 or

FAQ

All our tests that are for clinical decision making should be ordered by a licensed healthcare provider or a genetic counselor. Pharmacists play a critical role in integrating PGx into patient care. In the United States, in general, the pharmacists need collaborative practice agreements in place to order the test. However, certain States might have the specific state laws regulating pharmacists’ ability to order and interpret lab test.

If the specimen meets our quality requirements, a typical turnaround time for the test is 10-15 business days.

Patient’s out-of-pocket cost may vary depending on the patient’s health insurance plan. RPRD will contact the patient’s insurance provider to understand the potential total out-of-pocket cost (estimated only). We promise only to process the test if the patient is comfortable with the cost. RPRD also offers Financial Assistance Program to the eligible patients, to help reduce the out-of-pocket cost.

RPRD’s Financial Assistance Program 

We also offer patient self-pay option (U.S only).

Learn more on our self-pay page.

If you have any questions about your patient’s test result or need any help to understand the report, our board-certified medical geneticist and experienced PGx scientists are available to guide you through the test result and answer any questions.

We do not offer consultation to the patients directly.

 

Whole Pharmacogenomics Scan

Learn more about our most inclusive PGx testing.

Lab accreditation

All samples are processed in our CLIA-certified diagnostic laboratory with robust quality assurance programs that surpass required diagnostic testing standards.