Cytochrome p450, family 2, subfamily F, polypeptide 2 (CYP4F2) are primarily expressed in the liver and kidney. It catalyzes the metabolism of vitamin K and plays important role in limiting excessive accumulation of vitamin K.
Warfarin is the most commonly used oral anticoagulant worldwide. Warfarin dosing is especially challenging mainly due to its narrow therapeutic index and wide interpatient variability in pharmacokinetics. Several genes have been associated with the observed interpatient variability.1 Among all, CYP2C9, VKORC1, and CYP4F2 show the strongest evidence and are used by CPIC to provide recommendations for warfarin dosing.2
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- Whirl-Carrillo M, et al. Pharmacogenomics Knowledge for Personalized Medicine. Clin Pharmacol Ther. 2012;92(4):414-17.
- Johnson JA, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update. Clin Pharmacol Ther. 2017;102(3):397-404.