Science-Driven Innovations

Enabling precision medicine today, accelerating personalized therapies for tomorrow.
Pharmacogenomics and Precision Medicine

Science-Driven Innovations

Enabling precision medicine today, accelerating personalized therapies for tomorrow.

How Personalized Medicine Improves Patient Care

Not every drug works for every patient. The traditional trial-and-error method to prescribe therapy, at times, lead to adverse drug reactions (ADRs) and reduced drug efficacy. Thanks to the rapidly developing genomic medicine technologies, we have uncovered the associations between individual’s genetic profiles and response to certain drugs. This scientific breakthrough is called Pharmacogenomics, or PGx.

RPRD was founded in 2017 by scientists and clinicians from the Medical College of Wisconsin to use the PGx knowledge to personalize therapy, boosting drug safety and efficacy.

 

Why Partner with RPRD?

The most comprehensive PGx testing

RPRD’s flagship PGx testing, Whole Pharmacogenomics Scan (WPS®) is the most comprehensive, customizable, and scalable preemptive PGx test, which can analyze nearly all actionable pharmacogenetic genes of a patient with a single, one-time test.

 

PGx testing for diverse populations

RPRD’s PGx testing not only investigate the common genetic alleles, but also the rare and the ethnicity-specific variants, to generate inclusive and ethnicity-unbiased highly accurate testing results that every provider and patient can trust.

Leader in genomics research and clinical PGx testing

EMPOWER PERSONALIZED CARE

End-to-end solutions to enable precision medicine

We leverage advanced technologies and our decades-long experience in genetics research to bring pharmacogenetics into the mainstream. We empower clinicians with complete solutions, so they can focus on providing better care for their patients.

Evidence-based high-quality solutions

Our PGx solutions are formulated based on the latest clinical practice guidelines, which are supported by rigorous peer-reviewed clinical and scientific evidence.

Genetics in Drug Responses

ACCELERATE PERSONALIZED THERAPIES

Our drug development partners trust our academic excellence and decades of scientific research experience in genetics and the impact of genetics on drug responses. Through our continued research in modern technologies and drug R&D, we help our partners pursue personalized therapies to achieve better care for tomorrow.

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Latest Insights
Webinar Recording: Impact of CYP2D6 PGx

CYP2D6 is an important pharmacogenetics (PGx) gene as it is involved in the metablism of ~25% of clinically prescribed drugs. Dr. Cyrine-Eliana Haidar at St Jude Children’s Research Hospital will discuss how to use CYP2D6 genetic information to guide drug dosing and improve patient care, with focus on her many years of experience in managing the medications that are important in oncology care, including ondansetron, tamoxifen, select antidepressant and pain medicines.

Webinar Recording: PGx of Thiopurine Toxicity
Thiopurines are widely used as anti-cancer drugs and as immunosuppressive agents, but also have a narrow therapeutic index due to hematopoietic toxicities. Dr. Jun Yang at St Jude Children Research’s Hospital will discuss how preemptive dose adjustment based on the genetype information of TPMT and NUDT15 effectively minimizes the toxicities without compromising anti-cancer efficacy.
Podcast: the Voice of Healthcare

Dr. Hyun Kim, Clinical Pharmacist with Boston Children’s Clinical Pharmacogenomics Service and Dr. Ulrich (Uli) Broeckel, Founder and CEO of RPRD explore pharmacogenetics and precision medicine, the application to clinical medicine and decision making, and most importantly, the benefits to patients and clinical teams.

Understanding the relationship between an individual’s genetic profile and their pharmacokinetics is very important to our clinical studies. RPRD’s breadth of experience with comprehensive PGx-profiling tests and in-depth data analysis is exactly what we were looking for. I would highly recommend their services. 

- Simon Wong, Director, DMPK, Pliant Therapeutics

Unlock the power of science

RPRD is accelerating personalized therapies of tomorrow through its long-term commitment to advancing PGx with scientific breakthroughs and innovations.

PGx Diagnostic Solutions

RPRD’s experience in precision medicine and its CLIA-certified laboratory offer a wide range of PGx diagnostic services to meet your unique needs.

References
  1. Spear BB, et al. Clinical Application of Pharmacogenetics. Trends Mol. Med. 2001 May;7(5):201-4.
  2. FDA “Preventable Adverse Drug Reactions.” 2018.
  3. Relling MV, et al. Pharmacogenomics in the Clinic. Nature. 2015 Oct;526(7573):343-50.
  4. Ji Y, et al. Preemptive Pharmacogenomic Testing for Precision Medicine: A Comprehensive Analysis of Five Actionable Pharmacogenomic Genes Using Next-Generation DNA Sequencing and a Customized CYP2D6 Genotyping Cascade. J Mol. Diagn. 2016 May;18(3):438-46.
  5. Dunnenberger HM, et al. Preemptive Clinical Pharmacogenetics Implementation: Current Programs in Five US Medical Centers. Annu Rev Pharmacol Toxicol. 2015 Jan;55:89-106.